Name: Factor D inhibitor 6
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322462
Cas No:1386455-51-1
常用名:Factor D inhibitor 6
IUPAC:(1R,3S,5R)-2-(2-{3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl}acetyl)-N-[(1R)-1-(3-chloro-2-fluorophenyl)ethyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide
IUPAC:(1R,3S,5R)-2-(2-{3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl}acetyl)-N-[(1R)-1-(3-chloro-2-fluorophenyl)ethyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide
InChI key:YAALCKJNOOFODD-SKNMWMDOSA-N

分子式:C23H22ClFN6O3
分子量:484.92
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)N[C@H](C)c1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2ccncc12
SMILES:[H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)N[C@H](C)c1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2ccncc12

Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does not exhibit any inhibitory effects against factor B, classical and lectin complement-pathway activation, nor does it interfere with a broad array of receptors, ion channels, kinases, and proteases.

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