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  3. HIT214322541
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HIT214322541
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HIT214322541
  • HIT ID:HIT214322541
  • Cas No:142852-50-4
  • 常用名:Zanapezil free base
  • 别名:Zanapezil free base, TAK-147 free base
  • IUPAC:3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
    IUPAC:3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
  • InChI key:PMBLXLOXUGVTGB-UHFFFAOYSA-N
  • 分子式:C25H32N2O
  • 分子量:376.544
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCNc2c1
    SMILES:O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCNc2c1
  • Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM). Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD).
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 6,620.00
    1

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