MC-SN38 | MC-SN38 | CAS 1473403-87-0 | AnyMole

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HIT214322589

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HIT214322589

HIT ID:HIT214322589
Cas No:1473403-87-0
常用名:MC-SN38
别名:MC-SN38
IUPAC:(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
IUPAC:(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
InChI key:ACRMADURFCYBAU-YTTGMZPUSA-N

分子式:C32H31N3O8
分子量:585.613
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCN4C(=O)C=CC4=O)c3=O)-c2nc2ccc(O)cc12 |c:29|
SMILES:CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCN4C(=O)C=CC4=O)c3=O)-c2nc2ccc(O)cc12 |c:29|

MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks.

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