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  3. HIT214322603
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HIT214322603
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HIT214322603
  • HIT ID:HIT214322603
  • Cas No:1494684-28-4
  • 常用名:CYH33
  • IUPAC:methyl N-(5-{6-[(4-methanesulfonylpiperazin-1-yl)methyl]-4-(morpholin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl}-4-(trifluoromethyl)pyridin-2-yl)carbamate
    IUPAC:methyl N-(5-{6-[(4-methanesulfonylpiperazin-1-yl)methyl]-4-(morpholin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl}-4-(trifluoromethyl)pyridin-2-yl)carbamate
  • InChI key:KTLQDDGRBDLKMN-UHFFFAOYSA-N
  • 分子式:C24H29F3N8O5S
  • 分子量:598.6
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F
    SMILES:COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F
  • CYH33 is an orally active, highly selective PI3Kα inhibitor with IC 50 s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. CYH33 inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. CYH33 has potent activity against solid tumors.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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