Name: GS-493
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322749
Cas No:1710337-31-7
常用名:GS-493
IUPAC:4-{2-[(4Z)-1,3-bis(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}benzene-1-sulfonic acid
IUPAC:4-{2-[(4Z)-1,3-bis(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}benzene-1-sulfonic acid
InChI key:PKMKFRACKIHNRN-ATJXCDBQSA-N

分子式:C21H14N6O8S
分子量:510.44
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)N(=O)=O)c2ccc(cc2)N(=O)=O)cc1 |c:14|
SMILES:OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)N(=O)=O)c2ccc(cc2)N(=O)=O)cc1 |c:14|

GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~