Name: L-803087 TFA
Rating: 5 (10 reviews)

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HIT ID:HIT214322780
Cas No:1786412-46-1
常用名:L-803087 TFA
IUPAC:methyl (2S)-5-carbamimidamido-2-[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)butanamido]pentanoate; trifluoroacetic acid
IUPAC:methyl (2S)-5-carbamimidamido-2-[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)butanamido]pentanoate; trifluoroacetic acid
InChI key:IIRYZHRNVKQVGQ-BDQAORGHSA-N

分子式:C27H30F5N5O5
分子量:599.559
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.COC(=O)[C@H](CCCNC(N)=N)NC(=O)CCCc1c([nH]c2c(F)cc(F)cc12)-c1ccccc1
SMILES:OC(=O)C(F)(F)F.COC(=O)[C@H](CCCNC(N)=N)NC(=O)CCCc1c([nH]c2c(F)cc(F)cc12)-c1ccccc1

L-803087 TFA is a highly potent and selective agonist of the somatostatin sst4 receptor, exhibiting a Ki value of 0.7 nM. It displays a remarkable selectivity, being over 280-fold more preferential for the sst4 receptor compared to other somatostatin receptors. Furthermore, L-803087 TFA promotes AMPA-mediated synaptic responses in hippocampal preparations and enhances kainate-induced seizures in mice.

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