Name: RMC-3943
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322791
Cas No:1801764-60-2
常用名:RMC-3943
IUPAC:(1R)-8-{6-amino-5-[(2,3-dichloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-8-azaspiro[4.5]decan-1-amine
IUPAC:(1R)-8-{6-amino-5-[(2,3-dichloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-8-azaspiro[4.5]decan-1-amine
InChI key:PSKJCIJLNDJVDV-GFCCVEGCSA-N

分子式:C18H22Cl2N6S
分子量:425.38
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1
SMILES:N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1

RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM.

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