Name: Bis-sulfone-PEG4-DBCO
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT214322851
Cas No:1854034-70-0
常用名:Bis-sulfone-PEG4-DBCO
别名:Bis-sulfone-PEG4-DBCO
IUPAC:N-(3-{2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)-1-({4-[3-(4-methylbenzenesulfonyl)-2-[(4-methylbenzenesulfonyl)methyl]propanoyl]phenyl}formamido)-3,6,9,12-tetraoxapentadecan-15-amide
IUPAC:N-(3-{2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)-1-({4-[3-(4-methylbenzenesulfonyl)-2-[(4-methylbenzenesulfonyl)methyl]propanoyl]phenyl}formamido)-3,6,9,12-tetraoxapentadecan-15-amide
InChI key:ADIRLUISORIXON-UHFFFAOYSA-N

分子式:C54H59N3O12S2
分子量:1006.2
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc(cc1)S(=O)(=O)CC(CS(=O)(=O)c1ccc(C)cc1)C(=O)c1ccc(cc1)C(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12
SMILES:Cc1ccc(cc1)S(=O)(=O)CC(CS(=O)(=O)c1ccc(C)cc1)C(=O)c1ccc(cc1)C(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12

Bis-sulfone-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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