Name: MW-150 hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214322885
Cas No:1923773-01-6
常用名:MW-150 hydrochloride
别名:MW-150 hydrochloride, MW01-18-150SRM hydrochloride
别名:MW-150 hydrochloride, MW01-18-150SRM hydrochloride
IUPAC:6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine hydrochloride
IUPAC:6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine hydrochloride
InChI key:FQMOEAOQYORXPF-UHFFFAOYSA-N

分子式:C24H24ClN5
分子量:417.94
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1
SMILES:Cl.CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.

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