Name: DGN549-C
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322980
Cas No:2058075-34-4
常用名:DGN549-C
别名:DGN549-C
IUPAC:N-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]-N'-[(1S)-1-{[(1S)-1-{[3-({[(11S)-5-methoxy-2-oxo-1,9-diazatetracyclo[9.7.0.0^{3,8}.0^{13,18}]octadeca-3(8),4,6,13(18),14,16-hexaen-6-yl]oxy}methyl)-5-({[(11S)-5-methoxy-2-oxo-1,9-diazatetracyclo[9.7.0.0^{3,8}.0^{13,18}]octadeca-3,5,7,9,13(18),14,16-heptaen-6-yl]oxy}methyl)phenyl]carbamoyl}ethyl]carbamoyl}ethyl]hexanediamide
IUPAC:N-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]-N'-[(1S)-1-{[(1S)-1-{[3-({[(11S)-5-methoxy-2-oxo-1,9-diazatetracyclo[9.7.0.0^{3,8}.0^{13,18}]octadeca-3(8),4,6,13(18),14,16-hexaen-6-yl]oxy}methyl)-5-({[(11S)-5-methoxy-2-oxo-1,9-diazatetracyclo[9.7.0.0^{3,8}.0^{13,18}]octadeca-3,5,7,9,13(18),14,16-heptaen-6-yl]oxy}methyl)phenyl]carbamoyl}ethyl]carbamoyl}ethyl]hexanediamide
InChI key:ARZPUSPNNAYGKH-RCAQRAEBSA-N

分子式:C60H61N9O12
分子量:1100.199
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12Cc3ccccc3N1C(=O)c1cc(OC)c(OCc3cc(COc4cc5N=C[C@]6([H])Cc7ccccc7N6C(=O)c5cc4OC)cc(NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCCCC(=O)NCCN4C(=O)C=CC4=O)c3)cc1NC2 |c:30,80|
SMILES:[H][C@@]12Cc3ccccc3N1C(=O)c1cc(OC)c(OCc3cc(COc4cc5N=C[C@]6([H])Cc7ccccc7N6C(=O)c5cc4OC)cc(NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCCCC(=O)NCCN4C(=O)C=CC4=O)c3)cc1NC2 |c:30,80|

DGN549-C is a novel compound featuring a cleavable ADC (antibody-drug conjugate) linker composed of valine-alanine (va) and a PBD (pyrrolobenzodiazepine) dimer. This compound possesses a unique DNA-alkylating cytotoxic payload, DGN549, which is utilized in the development of ADCs.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~