Name: PCSK9-IN-2
Rating: 5 (10 reviews)

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HIT ID:HIT214323036
Cas No:2099167-44-7
常用名:PCSK9-IN-2
别名:PCSK9-IN-2
IUPAC:(3R)-1-{4-[(3R)-2,5-dioxo-3-{[(3R)-2-oxoazepan-3-yl]amino}pyrrolidin-1-yl]phenyl}-3-{[(3R)-2-oxoazepan-3-yl]amino}pyrrolidine-2,5-dione
IUPAC:(3R)-1-{4-[(3R)-2,5-dioxo-3-{[(3R)-2-oxoazepan-3-yl]amino}pyrrolidin-1-yl]phenyl}-3-{[(3R)-2-oxoazepan-3-yl]amino}pyrrolidine-2,5-dione
InChI key:HHZNNXTVGFYZFQ-UAFMIMERSA-N

分子式:C26H32N6O6
分子量:524.578
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O=C1C[C@@H](N[C@@H]2CCCCNC2=O)C(=O)N1c1ccc(cc1)N1C(=O)C[C@@H](N[C@@H]2CCCCNC2=O)C1=O
SMILES:O=C1C[C@@H](N[C@@H]2CCCCNC2=O)C(=O)N1c1ccc(cc1)N1C(=O)C[C@@H](N[C@@H]2CCCCNC2=O)C1=O

PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.

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