Name: eIF4A3-IN-5
Rating: 5 (10 reviews)

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HIT ID:HIT214323038
Cas No:2100145-31-9
常用名:eIF4A3-IN-5
别名:eIF4A3-IN-5
IUPAC:(2S,3R,4R,5S,6R)-6-(4-cyanophenyl)-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.0^{2,6}]dodeca-1(8),9,11-triene-4-carboxylic acid
IUPAC:(2S,3R,4R,5S,6R)-6-(4-cyanophenyl)-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.0^{2,6}]dodeca-1(8),9,11-triene-4-carboxylic acid
InChI key:UADSEUZFIUVZDF-YHVMUTAASA-N

分子式:C26H22N2O7
分子量:474.469
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)n1)C(O)=O)c1ccccc1)c1ccc(cc1)C#N
SMILES:COc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)n1)C(O)=O)c1ccccc1)c1ccc(cc1)C#N

eIF4A3-IN-5 is a highly effective inhibitor of eukaryotic initiation factor 4A (eIF4A), specifically targeting eIF4AI and eIF4AII. With its potent inhibitory properties, eIF4A3-IN-5 shows great potential for advancing research in eIF4A-dependent diseases, including cancer studies.

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