Name: IPN60090 dihydrochloride
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323052
Cas No:2102101-72-2
常用名:IPN60090 dihydrochloride
别名:IPN60090 dihydrochloride
IUPAC:1-[(2R)-4-(6-{2-[4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl]acetamido}pyridazin-3-yl)-2-fluorobutyl]-N-methyl-1H-1,2,3-triazole-4-carboxamide dihydrochloride
IUPAC:1-[(2R)-4-(6-{2-[4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl]acetamido}pyridazin-3-yl)-2-fluorobutyl]-N-methyl-1H-1,2,3-triazole-4-carboxamide dihydrochloride
InChI key:MREGZVYRKYDENT-QCUBGVIVSA-N

分子式:C24H29Cl2F3N8O3
分子量:605.44
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.CNC(=O)c1cn(C[C@H](F)CCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)cc(C)n3)nn2)nn1
SMILES:Cl.Cl.CNC(=O)c1cn(C[C@H](F)CCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)cc(C)n3)nn2)nn1

IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~