Name: Oritinib mesylate
Rating: 5 (10 reviews)

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HIT ID:HIT214323166
Cas No:2180164-79-6
常用名:Oritinib mesylate
别名:SH-1028 mesylate, Oritinib mesylate
IUPAC:N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-[(4-{6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}pyrimidin-2-yl)amino]phenyl)prop-2-enamide; methanesulfonic acid
IUPAC:N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-[(4-{6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl}pyrimidin-2-yl)amino]phenyl)prop-2-enamide; methanesulfonic acid
InChI key:IKCINODAIQYCSW-UHFFFAOYSA-N

分子式:C32H41N7O5S
分子量:635.78
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CS(O)(=O)=O.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c2CCCCn2c2ccccc12
SMILES:CS(O)(=O)=O.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c2CCCCn2c2ccccc12

Oritinib mesylate (SH-1028) is a highly selective, orally active, pyrimidine-based irreversible inhibitor of epidermal growth factor receptor (EGFR) with a low half maximal inhibitory concentration (IC50) of 18 nM. It demonstrates potent efficacy against both EGFR-sensitive and resistant (T790M) mutations. Furthermore, Oritinib mesylate effectively suppresses the proliferation of tumor cells harboring EGFR mutations, regardless of their sensitivity or resistance.

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