Name: Elomotecan hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214323176
Cas No:220997-99-9
常用名:Elomotecan hydrochloride
别名:BN 80927
IUPAC:(20R)-6-chloro-20-ethyl-20-hydroxy-7-methyl-10-[(4-methylpiperidin-1-yl)methyl]-17-oxa-3,13-diazapentacyclo[11.9.0.0^{2,11}.0^{4,9}.0^{15,21}]docosa-1(22),2,4,6,8,10,15(21)-heptaene-14,18-dione hydrochloride
IUPAC:(20R)-6-chloro-20-ethyl-20-hydroxy-7-methyl-10-[(4-methylpiperidin-1-yl)methyl]-17-oxa-3,13-diazapentacyclo[11.9.0.0^{2,11}.0^{4,9}.0^{15,21}]docosa-1(22),2,4,6,8,10,15(21)-heptaene-14,18-dione hydrochloride
InChI key:OLYFGLXPXPABOP-XXIQNXCHSA-N

分子式:C29H33Cl2N3O4
分子量:558.5
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CC[C@@]1(O)CC(=O)OCc2c1cc1-c3nc4cc(Cl)c(C)cc4c(CN4CCC(C)CC4)c3Cn1c2=O
SMILES:Cl.CC[C@@]1(O)CC(=O)OCc2c1cc1-c3nc4cc(Cl)c(C)cc4c(CN4CCC(C)CC4)c3Cn1c2=O

Elomotecan hydrochloride (BN 80927), a camptothecin analog from the homocamptothecin family (hCPT), is a highly potent inhibitor of both topoisomerases I and II. It demonstrates superior efficacy in reducing the proliferation of various tumor cells compared to other reference anticancer drugs targeting these topoisomerases.

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