Name: BRK inhibitor P21d hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214323254
Cas No:2250025-98-8
常用名:BRK inhibitor P21d hydrochloride
常用名:BRK inhibitor P21d hydrochloride
别名:BRK inhibitor P21d hydrochloride
IUPAC:6-cyclopropyl-N-[2-fluoro-4-(morpholine-4-carbonyl)phenyl]-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine hydrochloride
IUPAC:6-cyclopropyl-N-[2-fluoro-4-(morpholine-4-carbonyl)phenyl]-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine hydrochloride
InChI key:GWHGHKMCIUENCZ-UHFFFAOYSA-N

分子式:C23H23ClFN7O2
分子量:483.93
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Fc1cc(ccc1Nc1nc(cn2c(cnc12)-c1cn[nH]c1)C1CC1)C(=O)N1CCOCC1
SMILES:Cl.Fc1cc(ccc1Nc1nc(cn2c(cnc12)-c1cn[nH]c1)C1CC1)C(=O)N1CCOCC1

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.

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