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  3. HIT214323266
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HIT214323266
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HIT214323266
  • HIT ID:HIT214323266
  • Cas No:2253744-57-7
  • 常用名:TH5427 hydrochloride
  • IUPAC:7-{[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1,3-dimethyl-8-(piperazin-1-yl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione hydrochloride
    IUPAC:7-{[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1,3-dimethyl-8-(piperazin-1-yl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione hydrochloride
  • InChI key:IMMWMQVJIYSNKC-UHFFFAOYSA-N
  • 分子式:C20H21Cl3N8O3
  • 分子量:527.79
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O
    SMILES:Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O
  • TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 4,830.00
    1

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