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  3. HIT214323270
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HIT214323270
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HIT214323270
  • HIT ID:HIT214323270
  • Cas No:2253951-38-9
  • 常用名:LpxC-IN-5
  • IUPAC:2-amino-2-[(4-{2-[3-({2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl}methyl)-1,2-oxazol-5-yl]ethynyl}phenoxy)methyl]propane-1,3-diol
    IUPAC:2-amino-2-[(4-{2-[3-({2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl}methyl)-1,2-oxazol-5-yl]ethynyl}phenoxy)methyl]propane-1,3-diol
  • InChI key:DKGUWMFQYQOPSO-HNNXBMFYSA-N
  • 分子式:C21H24N4O5
  • 分子量:412.446
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:C[C@H](O)c1nccn1Cc1cc(on1)C#Cc1ccc(OCC(N)(CO)CO)cc1
    SMILES:C[C@H](O)c1nccn1Cc1cc(on1)C#Cc1ccc(OCC(N)(CO)CO)cc1
  • LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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