Name: RORγ agonist 1
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214323278
Cas No:2260631-91-0
常用名:RORγ agonist 1
IUPAC:2-{[4-chloro-2-(trifluoromethyl)phenyl]methyl}-N-[(1R)-1-[4-(ethanesulfonyl)phenyl]-2-hydroxyethyl]-1-(2-fluoroethyl)-1H-indole-5-carboxamide
IUPAC:2-{[4-chloro-2-(trifluoromethyl)phenyl]methyl}-N-[(1R)-1-[4-(ethanesulfonyl)phenyl]-2-hydroxyethyl]-1-(2-fluoroethyl)-1H-indole-5-carboxamide
InChI key:QZQCXURNZJAFEH-SANMLTNESA-N

分子式:C29H27ClF4N2O4S
分子量:611.05
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCS(=O)(=O)c1ccc(cc1)[C@H](CO)NC(=O)c1ccc2n(CCF)c(Cc3ccc(Cl)cc3C(F)(F)F)cc2c1
SMILES:CCS(=O)(=O)c1ccc(cc1)[C@H](CO)NC(=O)c1ccc2n(CCF)c(Cc3ccc(Cl)cc3C(F)(F)F)cc2c1

RORγ agonist 1 is a highly potent and orally bioavailable compound that activates the RORγ receptor. Its efficacy is demonstrated by an EC50 value of 21 nM and it exhibits antitumor activity.

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