Name: S2157
Rating: 5 (10 reviews)

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HIT ID:HIT214323280
Cas No:2262488-39-9
常用名:S2157
别名:S2157
IUPAC:2-{[(1R,2S)-2-[2-(benzyloxy)-3,5-difluorophenyl]cyclopropyl]amino}-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride
IUPAC:2-{[(1R,2S)-2-[2-(benzyloxy)-3,5-difluorophenyl]cyclopropyl]amino}-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride
InChI key:PUXYOFXCUCMFSQ-OZYANKIXSA-N

分子式:C23H28ClF2N3O2
分子量:451.94
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CN1CCN(CC1)C(=O)CN[C@@H]1C[C@H]1c1cc(F)cc(F)c1OCc1ccccc1
SMILES:Cl.CN1CCN(CC1)C(=O)CN[C@@H]1C[C@H]1c1cc(F)cc(F)c1OCc1ccccc1

S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted with T-ALL cells.

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