APJ receptor agonist 1 | CAS 2287153-38-0 | AnyMole

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HIT214323292

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HIT214323292

HIT ID:HIT214323292
Cas No:2287153-38-0
常用名:APJ receptor agonist 1
IUPAC:2'-(1H-1,3-benzodiazol-2-yl)-6'-chloro-4-[(1-phenylbutyl)carbamoyl]-[1,1'-biphenyl]-2-carboxylic acid
IUPAC:2'-(1H-1,3-benzodiazol-2-yl)-6'-chloro-4-[(1-phenylbutyl)carbamoyl]-[1,1'-biphenyl]-2-carboxylic acid
InChI key:KCWRZNXFHSFVKD-UHFFFAOYSA-N

分子式:C31H26ClN3O3
分子量:524.02
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCC(NC(=O)c1ccc(c(c1)C(O)=O)-c1c(Cl)cccc1-c1nc2ccccc2[nH]1)c1ccccc1
SMILES:CCCC(NC(=O)c1ccc(c(c1)C(O)=O)-c1c(Cl)cccc1-c1nc2ccccc2[nH]1)c1ccccc1

APJ receptor agonist 1, a potent biphenyl acid derivative, acts as an agonist (EC50 of 0.093 nM and 0.12 nM for human and rat APJ receptors, respectively) for the APJ receptor (APJ-R). It exhibits significant in vitro potency towards apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 holds promise for heart failure research.

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TargetMolSC
规格
货期
6-8周
纯度
-
¥ 10,600.00
1

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