Name: Desmorpholinyl Quizartinib-PEG2-COOH
Rating: 5 (10 reviews)

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HIT ID:HIT214323297
Cas No:2292116-14-2
常用名:Desmorpholinyl Quizartinib-PEG2-COOH
常用名:Desmorpholinyl Quizartinib-PEG2-COOH
别名:Desmorpholinyl Quizartinib-PEG2-COOH
IUPAC:3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,5,8,10-pentaen-10-yl]oxy}ethoxy)ethoxy]propanoic acid
IUPAC:3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,5,8,10-pentaen-10-yl]oxy}ethoxy)ethoxy]propanoic acid
InChI key:BMRGZWDBDUKFLR-UHFFFAOYSA-N

分子式:C30H33N5O7S
分子量:607.68
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1
SMILES:CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1

Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.

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