Name: NVP-BSK805 trihydrochloride
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT214323323
Cas No:2320258-95-3
常用名:NVP-BSK805 trihydrochloride
别名:NVP-BSK805 trihydrochloride
IUPAC:8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline trihydrochloride
IUPAC:8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline trihydrochloride
InChI key:VWBSZLCFZWKXHV-UHFFFAOYSA-N

分子式:C27H31Cl3F2N6O
分子量:599.93
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.Cl.Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1
SMILES:Cl.Cl.Cl.Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1

NVP-BSK805 trihydrochloride is a potent ATP-competitive inhibitor of JAK2, exhibiting IC50 values of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM against JAK2 JH1, JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

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