Name: GSK143 dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214323339
Cas No:2341796-81-2
常用名:GSK143 dihydrochloride
IUPAC:2-{[(3R,4R)-3-aminooxan-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide dihydrochloride
IUPAC:2-{[(3R,4R)-3-aminooxan-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide dihydrochloride
InChI key:UEHPBSLIDBDMCZ-WICJZZOFSA-N

分子式:C17H24Cl2N6O2
分子量:415.32
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
SMILES:Cl.Cl.Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1

GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The compound demonstrates anti-inflammatory properties and hinders the recruitment of immune cells in the intestinal muscularis of mice.

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