Name: IDO1-IN-7
Rating: 5 (10 reviews)

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HIT ID:HIT214323345
Cas No:2351199-98-7
常用名:IDO1-IN-7
别名:IDO1-IN-7
IUPAC:N-(4-chlorophenyl)-2-[(3R,4R)-4-(6-fluoroquinolin-4-yl)-3-hydroxypiperidin-1-yl]-2-oxoacetamide
IUPAC:N-(4-chlorophenyl)-2-[(3R,4R)-4-(6-fluoroquinolin-4-yl)-3-hydroxypiperidin-1-yl]-2-oxoacetamide
InChI key:GZSMNWZYUMDTHO-XLIONFOSSA-N

分子式:C22H19ClFN3O3
分子量:427.86
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O[C@H]1CN(CC[C@@H]1c1ccnc2ccc(F)cc12)C(=O)C(=O)Nc1ccc(Cl)cc1
SMILES:O[C@H]1CN(CC[C@@H]1c1ccnc2ccc(F)cc12)C(=O)C(=O)Nc1ccc(Cl)cc1

IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.

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