Name: SR-717 free acid
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323375
Cas No:2375420-34-9
常用名:SR-717 free acid
IUPAC:4,5-difluoro-2-[6-(1H-imidazol-1-yl)pyridazine-3-amido]benzoic acid
IUPAC:4,5-difluoro-2-[6-(1H-imidazol-1-yl)pyridazine-3-amido]benzoic acid
InChI key:WEBVQIJGIZVRGA-UHFFFAOYSA-N

分子式:C15H9F2N5O3
分子量:345.266
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
SMILES:OC(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1

SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.

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