Name: Zeteletinib hemiadipate
Rating: 5 (10 reviews)

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HIT ID:HIT214323376
Cas No:2375837-06-0
常用名:Zeteletinib hemiadipate
别名:Zeteletinib hemiadipate, DS-5010hemiadipate, BOS-172738 hemiadipate
别名:Zeteletinib hemiadipate, DS-5010hemiadipate, BOS-172738 hemiadipate
IUPAC:bis(2-[6-(6,7-dimethoxyquinolin-3-yl)pyridin-3-yl]-N-[3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-5-yl]acetamide); hexanedioic acid
IUPAC:bis(2-[6-(6,7-dimethoxyquinolin-3-yl)pyridin-3-yl]-N-[3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-5-yl]acetamide); hexanedioic acid
InChI key:KIKHVJAFGVCFGH-UHFFFAOYSA-N

分子式:C56H56F6N8O12
分子量:1147.098
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)CCCCC(O)=O.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1
SMILES:OC(=O)CCCCC(O)=O.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1

Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects.

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