Name: HSD1590
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214323390
Cas No:2379279-96-4
常用名:HSD1590
IUPAC:(2-methoxy-3-{4,5,10-triazatetracyclo[7.7.0.0^{2,6}.0^{12,16}]hexadeca-1(9),2(6),3,7,10,12(16)-hexaen-11-yl}phenyl)boronic acid
IUPAC:(2-methoxy-3-{4,5,10-triazatetracyclo[7.7.0.0^{2,6}.0^{12,16}]hexadeca-1(9),2(6),3,7,10,12(16)-hexaen-11-yl}phenyl)boronic acid
InChI key:WTZMCUOBQPTERK-UHFFFAOYSA-N

分子式:C20H18BN3O3
分子量:359.19
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1c(cccc1-c1nc2ccc3[nH]ncc3c2c2CCCc12)B(O)O
SMILES:COc1c(cccc1-c1nc2ccc3[nH]ncc3c2c2CCCc12)B(O)O

HSD1590 is a highly effective and potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.22 nM and 0.51 nM, respectively. It demonstrates exceptional binding affinity to ROCK, with Kd values below 2 nM. Moreover, HSD1590 showcases minimal cytotoxicity, making it an ideal compound for various applications.

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