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  3. HIT214323402
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HIT214323402
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HIT214323402
  • HIT ID:HIT214323402
  • Cas No:2387505-59-9
  • 常用名:AP14145 hydrochloride
  • IUPAC:N-(2-{[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino}-1H-1,3-benzodiazol-7-yl)acetamide hydrochloride
    IUPAC:N-(2-{[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino}-1H-1,3-benzodiazol-7-yl)acetamide hydrochloride
  • InChI key:KGIUXIYNTCVBST-HNCPQSOCSA-N
  • 分子式:C18H18ClF3N4O
  • 分子量:398.81
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F
    SMILES:Cl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F
  • AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 7,830.00
    1

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