Name: RMC-6272
Rating: 5 (10 reviews)

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HIT ID:HIT214323404
Cas No:2382769-46-0
常用名:RMC-6272
别名:RMC-6272, RM-006
IUPAC:(1R,2R,4S)-2-methoxy-4-[(2R)-2-[(1R,9S,12S,14R,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,14,18-trihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,20-tetraoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]cyclohexyl N-{26-[(2-{4-[7-(6-aminopyridin-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-4-carbonyl]-2-fluoro-3-methylbenzenesulfonyl}ethyl)carbamoyl]-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl}carbamate
IUPAC:(1R,2R,4S)-2-methoxy-4-[(2R)-2-[(1R,9S,12S,14R,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,14,18-trihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,20-tetraoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]cyclohexyl N-{26-[(2-{4-[7-(6-aminopyridin-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-4-carbonyl]-2-fluoro-3-methylbenzenesulfonyl}ethyl)carbamoyl]-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl}carbamate
InChI key:SBCMKKFTXRBACH-BRWZYJNRSA-N

分子式:C95H141FN6O27S
分子量:1850.25
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(C[C@@H](O)[C@H](C)\C=C(C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C/C=C\C=C(C)/[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCS(=O)(=O)c2ccc(C(=O)N3CCOc4ccc(cc4C3)-c3ccc(N)nc3)c(C)c2F)[C@@H](C1)OC |c:47,49,t:32,51|
SMILES:[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(C[C@@H](O)[C@H](C)\C=C(C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C/C=C\C=C(C)/[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCS(=O)(=O)c2ccc(C(=O)N3CCOc4ccc(cc4C3)-c3ccc(N)nc3)c(C)c2F)[C@@H](C1)OC |c:47,49,t:32,51|

RMC-6272 (RM-006) is a bi-steric inhibitor that selectively targets mTORC1, displaying potent and selective (> 10-fold) inhibition over mTORC2. Compared to Rapamycin, RMC-6272 demonstrates enhanced inhibition of mTORC1 and induces increased cell death in TSC2 null tumors.

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