Name: BET bromodomain inhibitor 1
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323443
Cas No:2411226-02-1
常用名:BET bromodomain inhibitor 1
IUPAC:6-[2-(2,4-difluorophenoxy)-5-[(ethanesulfonyl)methyl]pyridin-3-yl]-8-methyl-1H,2H-pyrrolo[1,2-a]pyrazin-1-one
IUPAC:6-[2-(2,4-difluorophenoxy)-5-[(ethanesulfonyl)methyl]pyridin-3-yl]-8-methyl-1H,2H-pyrrolo[1,2-a]pyrazin-1-one
InChI key:UETQFSCWDMJWMM-UHFFFAOYSA-N

分子式:C22H19F2N3O4S
分子量:459.47
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCS(=O)(=O)Cc1cnc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c2n1cc[nH]c2=O
SMILES:CCS(=O)(=O)Cc1cnc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c2n1cc[nH]c2=O

BET bromodomain inhibitor 1 is an orally active, selective inhibitor of bromodomain and extra-terminal (BET) proteins. It specifically inhibits BRD4 with an IC50 of 2.6 nM. Additionally, BET bromodomain inhibitor 1 demonstrates high affinities towards BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, and 2.1 nM, respectively. This compound exhibits anti-cancer activity.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~