Name: Nicotinamide riboside malate
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214323469
Cas No:2415659-01-5
常用名:Nicotinamide riboside malate
别名:烟酰胺核糖苹果酸盐
IUPAC:3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium (3R)-3-carboxy-3-hydroxypropanoate
IUPAC:3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium (3R)-3-carboxy-3-hydroxypropanoate
InChI key:CCIJCSINBFLRRP-ARAVNFEUSA-N

分子式:C15H20N2O10
分子量:388.329
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O[C@H](CC([O-])=O)C(O)=O.NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
SMILES:O[C@H](CC([O-])=O)C(O)=O.NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.

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