Name: DDR1-IN-5
Rating: 5 (10 reviews)

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HIT ID:HIT214323471
Cas No:2416022-90-5
常用名:DDR1-IN-5
别名:DDR1-IN-5
IUPAC:7-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-6-methyl-N-[5-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
IUPAC:7-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-6-methyl-N-[5-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
InChI key:LGHRUPKASNQBFS-UHFFFAOYSA-N

分子式:C22H13F3N6O
分子量:434.382
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc2c(Nc3cncc(c3)C(F)(F)F)noc2c1C#Cc1cnc2cccnn12
SMILES:Cc1ccc2c(Nc3cncc(c3)C(F)(F)F)noc2c1C#Cc1cnc2cccnn12

DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.

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