Name: BMS-1166-N-piperidine-COOH
Rating: 5 (10 reviews)

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HIT ID:HIT214323509
Cas No:2447066-00-2
常用名:BMS-1166-N-piperidine-COOH
IUPAC:1-({5-chloro-2-[(3-cyanophenyl)methoxy]-4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}phenyl}methyl)piperidine-2-carboxylic acid
IUPAC:1-({5-chloro-2-[(3-cyanophenyl)methoxy]-4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}phenyl}methyl)piperidine-2-carboxylic acid
InChI key:RELGDHKISWTSBN-UHFFFAOYSA-N

分子式:C37H35ClN2O6
分子量:639.15
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
SMILES:Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1

BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

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