Name: BMS-1166-N-piperidine-CO-N-piperazine
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323510
Cas No:2447066-14-8
常用名:BMS-1166-N-piperidine-CO-N-piperazine
常用名:BMS-1166-N-piperidine-CO-N-piperazine
IUPAC:3-[(4-chloro-5-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-{[2-(piperazine-1-carbonyl)piperidin-1-yl]methyl}phenoxy)methyl]benzonitrile
IUPAC:3-[(4-chloro-5-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-{[2-(piperazine-1-carbonyl)piperidin-1-yl]methyl}phenoxy)methyl]benzonitrile
InChI key:IYPYUVUFRCLTFR-UHFFFAOYSA-N

分子式:C41H43ClN4O5
分子量:707.27
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
SMILES:Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1

BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound that contains a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It can be utilized in the synthesis of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits the PD-1/PD-L1 interaction, demonstrating an IC50 value of 39.2 nM.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~