Name: eIF4E-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT214323594
Cas No:2573979-31-2
常用名:eIF4E-IN-1
别名:eIF4E-IN-1
IUPAC:7-(5-chloro-2-{2-[5-cyano-2-methyl-6-(4-methylpiperazin-1-yl)-4-oxo-7-(trifluoromethyl)-3,4-dihydroquinazolin-3-yl]ethoxy}phenyl)-5-methylthieno[3,2-b]pyridine-3-carboxylic acid
IUPAC:7-(5-chloro-2-{2-[5-cyano-2-methyl-6-(4-methylpiperazin-1-yl)-4-oxo-7-(trifluoromethyl)-3,4-dihydroquinazolin-3-yl]ethoxy}phenyl)-5-methylthieno[3,2-b]pyridine-3-carboxylic acid
InChI key:DVOYANWINMPDSB-UHFFFAOYSA-N

分子式:C33H28ClF3N6O4S
分子量:697.13
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN1CCN(CC1)c1c(C#N)c2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O
SMILES:CN1CCN(CC1)c1c(C#N)c2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O

eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.

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