Name: EEDi-5273
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214323604
Cas No:2585648-55-9
常用名:EEDi-5273
IUPAC:15-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-9-(propan-2-yl)-5-(trifluoromethyl)-4,9,12,14,16-pentaazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(17),2,4,6,11(18),12,15-heptaen-10-one
IUPAC:15-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-9-(propan-2-yl)-5-(trifluoromethyl)-4,9,12,14,16-pentaazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(17),2,4,6,11(18),12,15-heptaen-10-one
InChI key:OAYMRNSLBKYMKG-UHFFFAOYSA-N

分子式:C26H22F4N6O2
分子量:526.496
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)N1Cc2cc(ncc2-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C1=O)c23)C(F)(F)F
SMILES:CC(C)N1Cc2cc(ncc2-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C1=O)c23)C(F)(F)F

EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumors.

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