Name: JNK3 inhibitor-1
Rating: 5 (10 reviews)

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HIT ID:HIT214323625
Cas No:2622877-97-6
常用名:JNK3 inhibitor-1
别名:JNK3 inhibitor-1
IUPAC:4-{5-[(2-chloro-6-fluorophenyl)amino]-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl}-N-(oxetan-3-yl)thiophene-2-carboxamide
IUPAC:4-{5-[(2-chloro-6-fluorophenyl)amino]-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl}-N-(oxetan-3-yl)thiophene-2-carboxamide
InChI key:KDMADGZAPDHVHE-UHFFFAOYSA-N

分子式:C21H17ClFN5O2S
分子量:457.91
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1nc2n(ncc2cc1Nc1c(F)cccc1Cl)-c1csc(c1)C(=O)NC1COC1
SMILES:Cc1nc2n(ncc2cc1Nc1c(F)cccc1Cl)-c1csc(c1)C(=O)NC1COC1

JNK3 inhibitor-1 is a highly potent and selective compound that specifically inhibits JNK3 with an impressive IC50 value of 0.005 μM. In addition to its remarkable inhibitory effects, JNK3 inhibitor-1 possesses excellent oral bioavailability and the ability to efficiently penetrate the brain.

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