Name: β-Secretase Inhibitor II
Rating: 5 (10 reviews)

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HIT ID:HIT214323635
Cas No:263563-09-3
常用名:β-Secretase Inhibitor II
IUPAC:benzyl N-[(1S)-2-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}propyl]carbamate
IUPAC:benzyl N-[(1S)-2-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}propyl]carbamate
InChI key:YHUAFMGVVANYBT-FKBYEOEOSA-N

分子式:C25H39N3O5
分子量:461.603
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C=O |@:28|
SMILES:CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C=O |@:28|

β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specifically against Aβ 1-42. This compound is particularly useful in research related to Alzheimer's disease.

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