Name: RM-018
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323643
Cas No:2641993-55-5
常用名:RM-018
IUPAC:N-{22-ethyl-21-[2-(1-methoxyethyl)pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1^{2,6}.1^{10,14}.0^{23,27}]nonacosa-1(25),2,4,6(29),20,23,26-heptaen-8-yl}-3-methyl-2-(N-methyl-1-{1-[4-(morpholin-4-yl)but-2-ynoyl]pyrrolidin-3-yl}formamido)butanamide
IUPAC:N-{22-ethyl-21-[2-(1-methoxyethyl)pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1^{2,6}.1^{10,14}.0^{23,27}]nonacosa-1(25),2,4,6(29),20,23,26-heptaen-8-yl}-3-methyl-2-(N-methyl-1-{1-[4-(morpholin-4-yl)but-2-ynoyl]pyrrolidin-3-yl}formamido)butanamide
InChI key:KXMPBNBAZLJBDS-UHFFFAOYSA-N

分子式:C56H72N8O8
分子量:985.24
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCn1c(c2CC(C)(C)COC(=O)C3CCCN(N3)C(=O)C(Cc3cccc(c3)-c3ccc1c2c3)NC(=O)C(C(C)C)N(C)C(=O)C1CCN(C1)C(=O)C#CCN1CCOCC1)-c1cccnc1C(C)OC
SMILES:CCn1c(c2CC(C)(C)COC(=O)C3CCCN(N3)C(=O)C(Cc3cccc(c3)-c3ccc1c2c3)NC(=O)C(C(C)C)N(C)C(=O)C1CCN(C1)C(=O)C#CCN1CCOCC1)-c1cccnc1C(C)OC

RM-018 is a powerful tricomplex inhibitor that specifically targets the active state of KRAS G12C. It exhibits unique functional characteristics and possesses the ability to bind and inhibit both KRAS G12C and KRAS G12C/Y96D, potentially overcoming resistance.

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