Name: DSM705
Rating: 5 (10 reviews)

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HIT ID:HIT214323664
Cas No:2653225-38-6
常用名:DSM705
别名:DSM705
IUPAC:3-methyl-N-[(1R)-1-(4H-1,2,4-triazol-3-yl)ethyl]-4-{1-[6-(trifluoromethyl)pyridin-3-yl]cyclopropyl}-1H-pyrrole-2-carboxamide
IUPAC:3-methyl-N-[(1R)-1-(4H-1,2,4-triazol-3-yl)ethyl]-4-{1-[6-(trifluoromethyl)pyridin-3-yl]cyclopropyl}-1H-pyrrole-2-carboxamide
InChI key:JUBPRXDFKLPILK-LLVKDONJSA-N

分子式:C19H19F3N6O
分子量:404.397
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@@H](NC(=O)c1[nH]cc(c1C)C1(CC1)c1ccc(nc1)C(F)(F)F)c1nnc[nH]1
SMILES:C[C@@H](NC(=O)c1[nH]cc(c1C)C1(CC1)c1ccc(nc1)C(F)(F)F)c1nnc[nH]1

DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHODHs. DSM705 shows significant efficacy as an antimalarial compound.

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