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  3. HIT214323682
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HIT214323682
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HIT214323682
  • HIT ID:HIT214323682
  • Cas No:2687273-52-3
  • 常用名:PARP/EZH2-IN-1
  • 别名:PARP/EZH2-IN-1
  • IUPAC:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-acetamido-5-[6-(4-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazin-1-yl)pyridin-3-yl]-2-methylbenzamide
    IUPAC:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-acetamido-5-[6-(4-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazin-1-yl)pyridin-3-yl]-2-methylbenzamide
  • InChI key:VKTSBOIQJNMQAL-UHFFFAOYSA-N
  • 分子式:C43H41FN8O5
  • 分子量:768.85
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(=O)Nc1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
    SMILES:CC(=O)Nc1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
  • PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type BRCA.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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