Name: ZXH-4-130
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323704
Cas No:2711006-66-3
常用名:ZXH-4-130
IUPAC:(2S,4R)-1-[(2S)-2-(11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-[(2S)-2-(11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
InChI key:CZQHTMJBCZCOMW-ZALOBHIXSA-N

分子式:C46H58N6O9S
分子量:871.06
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCOc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCOc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1

ZXH-4-130 is a potent and selective CRBN degrader, functioning as a hetero-PROTAC compound with the inclusion of CRBN-VHL.

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