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  3. HIT214323723
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HIT214323723
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HIT214323723
  • HIT ID:HIT214323723
  • Cas No:2747919-19-1
  • 常用名:CDK7/9-IN-1
  • 别名:CDK7/9-IN-1
  • IUPAC:1-[(2R)-2-[(4-{[3-(propan-2-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl]amino}piperidin-1-yl)methyl]morpholin-4-yl]prop-2-en-1-one
    IUPAC:1-[(2R)-2-[(4-{[3-(propan-2-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl]amino}piperidin-1-yl)methyl]morpholin-4-yl]prop-2-en-1-one
  • InChI key:NLPHXSGNLCQYEN-LJQANCHMSA-N
  • 分子式:C24H32F3N5O2
  • 分子量:479.548
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(C)c1cnc2c(NC3CCN(C[C@@H]4CN(CCO4)C(=O)C=C)CC3)cc(cn12)C(F)(F)F
    SMILES:CC(C)c1cnc2c(NC3CCN(C[C@@H]4CN(CCO4)C(=O)C=C)CC3)cc(cn12)C(F)(F)F
  • CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for such investigations.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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