Name: Namoline
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT214323772
Cas No:342795-11-3
常用名:Namoline
别名:萘莫胺
IUPAC:3-chloro-6-nitro-2-(trifluoromethyl)-4H-chromen-4-one
IUPAC:3-chloro-6-nitro-2-(trifluoromethyl)-4H-chromen-4-one
InChI key:DYEGRZKBJMKSKD-UHFFFAOYSA-N

分子式:C10H3ClF3NO4
分子量:293.58
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:FC(F)(F)c1oc2ccc(cc2c(=O)c1Cl)N(=O)=O
SMILES:FC(F)(F)c1oc2ccc(cc2c(=O)c1Cl)N(=O)=O

Namoline is a γ-pyrone compound that functions as a selective and reversible inhibitor of Lysine-specific demethylase 1 (LSD1) with an IC50 of 51 μM in an HRP-coupled enzymatic assay. By impairing LSD1 demethylase activity, Namoline effectively inhibits cell proliferation. Due to its characteristics, Namoline holds promise for research pertaining to androgen-dependent prostate cancer.

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