Name: Mezerein
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214323782
Cas No:34807-41-5
常用名:Mezerein
别名:欧瑞香脂, 密执毒素
IUPAC:(1R,2R,6S,7S,8R,10S,11S,12R,14S,16S,17R,18R)-6,7-dihydroxy-8-(hydroxymethyl)-4,18-dimethyl-5-oxo-14-phenyl-16-(prop-1-en-2-yl)-9,13,15,19-tetraoxahexacyclo[12.4.1.0^{1,11}.0^{2,6}.0^{8,10}.0^{12,16}]nonadec-3-en-17-yl (2E,4E)-5-phenylpenta-2,4-dienoate
IUPAC:(1R,2R,6S,7S,8R,10S,11S,12R,14S,16S,17R,18R)-6,7-dihydroxy-8-(hydroxymethyl)-4,18-dimethyl-5-oxo-14-phenyl-16-(prop-1-en-2-yl)-9,13,15,19-tetraoxahexacyclo[12.4.1.0^{1,11}.0^{2,6}.0^{8,10}.0^{12,16}]nonadec-3-en-17-yl (2E,4E)-5-phenylpenta-2,4-dienoate
InChI key:DLEDLHFNQDHEOJ-UDTOXTEMSA-N

分子式:C38H38O10
分子量:654.712
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12O[C@]1(CO)[C@@H](O)[C@]1(O)C(=O)C(C)=C[C@@]1([H])[C@]13O[C@@]4(O[C@]([H])([C@]21[H])[C@@](O4)([C@H](OC(=O)\C=C\C=C\c1ccccc1)[C@H]3C)C(C)=C)c1ccccc1 |c:14,TLB:46:19:23:41.25.27,1:23:25.26:20,THB:41:17:25.26:20,27:25:17.23.18:20,26:19:23:41.25.27|
SMILES:[H][C@@]12O[C@]1(CO)[C@@H](O)[C@]1(O)C(=O)C(C)=C[C@@]1([H])[C@]13O[C@@]4(O[C@]([H])([C@]21[H])[C@@](O4)([C@H](OC(=O)\C=C\C=C\c1ccccc1)[C@H]3C)C(C)=C)c1ccccc1 |c:14,TLB:46:19:23:41.25.27,1:23:25.26:20,THB:41:17:25.26:20,27:25:17.23.18:20,26:19:23:41.25.27|

Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC.

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