Name: 3-Methylthienyl-carbonyl-JNJ-7706621
Rating: 5 (10 reviews)

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HIT ID:HIT214323852
Cas No:443798-09-2
常用名:3-Methylthienyl-carbonyl-JNJ-7706621
常用名:3-Methylthienyl-carbonyl-JNJ-7706621
IUPAC:4-{[5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide
IUPAC:4-{[5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide
InChI key:KQWTXAWKBUUOMU-UHFFFAOYSA-N

分子式:C14H14N6O3S2
分子量:378.43
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
SMILES:Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N

3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK). It exhibits impressive IC50 values of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, 3-Methylthienyl-carbonyl-JNJ-7706621 demonstrates potent inhibition against GSK-3 (IC50 = 0.041 μM) and moderate potency towards CDK4, VEGF-R2, and FGF-R2 (IC50 = 0.11 μM, 0.13 μM, and 0.22 μM, respectively). Its applications in cancer research are noteworthy.

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