Name: Glabrescione B
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214323976
Cas No:65893-94-9
常用名:Glabrescione B
IUPAC:3-{3,4-bis[(3-methylbut-2-en-1-yl)oxy]phenyl}-5,7-dimethoxy-4H-chromen-4-one
IUPAC:3-{3,4-bis[(3-methylbut-2-en-1-yl)oxy]phenyl}-5,7-dimethoxy-4H-chromen-4-one
InChI key:RHXDATRKLOYVTC-UHFFFAOYSA-N

分子式:C27H30O6
分子量:450.531
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[#6]-[#8]-c1cc(-[#8]-[#6])c2c(c1)occ(-c1ccc(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])c1)c2=O
SMILES:[#6]-[#8]-c1cc(-[#8]-[#6])c2c(c1)occ(-c1ccc(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])c1)c2=O

Glabrescione B is a novel compound that specifically binds to Gli1, an important modulator of the Hedgehog (Hh) signaling pathway. By disrupting the Gli1-DNA interaction, Glabrescione B effectively impairs the activity of Gli1. Moreover, Glabrescione B demonstrates potent inhibitory effects on the growth of tumor cells that rely on Hedgehog signaling, as well as on the self-renewal capacity and clonogenicity of tumor-derived stem cells.

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