Name: NMDA receptor antagonist 2
Rating: 5 (10 reviews)

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HIT ID:HIT214324139
Cas No:875898-41-2
常用名:NMDA receptor antagonist 2
IUPAC:N-[(1S,3S)-3-{3-[(4-methylphenyl)methyl]-1,2,4-oxadiazol-5-yl}cyclopentyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
IUPAC:N-[(1S,3S)-3-{3-[(4-methylphenyl)methyl]-1,2,4-oxadiazol-5-yl}cyclopentyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChI key:JTKNIJDRSHYXLX-GJZGRUSLSA-N

分子式:C20H21N7O
分子量:375.436
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc(Cc2noc(n2)[C@H]2CC[C@@H](C2)Nc2ncnc3[nH]ncc23)cc1
SMILES:Cc1ccc(Cc2noc(n2)[C@H]2CC[C@@H](C2)Nc2ncnc3[nH]ncc23)cc1

NMDA receptor antagonist 2 is a highly potent and orally active NR2B subtype-selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. It exhibits remarkable binding affinities, with an IC50 of 1.0 nM and a Ki value of 0.88 nM. This compound finds valuable application in scientific investigations focusing on neuropathic pain and Parkinson’s disease.

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