Name: UK122
Rating: 5 (10 reviews)

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HIT ID:HIT214324191
Cas No:940290-58-4
常用名:UK122
别名:UK122
IUPAC:4-[(5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene)methyl]benzene-1-carboximidamide
IUPAC:4-[(5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene)methyl]benzene-1-carboximidamide
InChI key:JBHISGPWLXASFE-UHFFFAOYSA-N

分子式:C17H13N3O2
分子量:291.31
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:NC(=N)c1ccc(C=C2N=C(OC2=O)c2ccccc2)cc1 |w:7.6,c:9|
SMILES:NC(=N)c1ccc(C=C2N=C(OC2=O)c2ccccc2)cc1 |w:7.6,c:9|

UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.

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